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Thus, we hypothesized that PTX resistance could be transmitted from drug-resistant cells to sensitive cells via supernatant-mediated communication

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The net effect is a half-life of approximately 2030 hours compared to the 1215 minutes of free native IGF-1, and a substantially elevated free peptide fraction that is available for receptor engagement

Comment: Several commenters stated the proposal may violate the Administrative Procedure Act (5 U.S.C